LIU Depei
Professor Liu Depei
Biography

Prof. LIU Depei  is a medical molecular biologist. He graduated from Peking Union Medical College with a Ph.D. degree of biochemistry and molecular biology in 1986. During 1987-1990, he worked as a postdoctoral research fellow at the University of California, San Francisco in the United States. Now he is a professor and doctoral supervisor.

He served as President of Chinese Academy of Medical Sciences(CAMS) and Peking Union Medical College (PUMC) during the year of 2001-2011, and Vice President of Chinese academy of engineering(CAE) during the year of 2002-2010. He was elected the member of Chinese Academy of Engineering (CAE) in 1996, and the member of the U.S. Institute of Medicine (IOM) and the Third World Academy of Sciences (TWAS) in 2008. He is also the member of the eleventh and twelfth session of the Standing Committee of the National People's Congress of China.

At the National Laboratory of Medical Molecular Biology, Dr. Liu has been engaged in researches on molecular biology about the regulation of gene expression, transgenic animals and disease models, gene transfer and gene therapy. In the studies of the regulation of hemoglobin gene expression and gene therapy for β-thalassemia, he discovered firstly erythrotic specific enhancer (HS2) of β-globin gene and its critical NFE 2/AP I site, discovered that erythrotic specific enhancers in different lengths enhance β-globin gene expression level in retrovirus vector mediated gene transfer, and established transgenic mouse models of β E and β41/42 genes. Dr. Liu also found that TC1 transposon inversion in high frequency in mammalian cells, proved Locus Control Region and proximal regulation elements corporately direct developmental regulation of β-globin gene cluster, created BAC mediated a/b-gene cluster and human apolipoprotein AI/CIII/AIV/AV gene cluster transgenic animal models, discovered that Myleran could enhance fetal γ-globin gene expression level apparently in adult anemic Rhesus monkeys and β-thalassemia patients, and completed β-globin gene site specific mutation by chimeric Due to his prominent work and achievements in scientific research and administrative management, Dr. Liu was awarded several times by the State Council, Ministry of Education, Ministry of Health of P. R. China and Beijing Municipal Government.

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