Dr. De-Pei Liu graduated with a Ph.D. from CAMS & PUMC in 1986. He completed his Postdoctoral Fellowship in molecular biology at University of California, San Francisco (UCSF). Dr. Liu is currently a professor of National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC). He is also serving as a member of Chinese Academy of Engineering (CAE), member of National Academy of Medicine (NAM) of USA, member of Third World Academy of Sciences (TWAS), and Co-chair of IAP Health (InterAcademy Panel for Health).
Dr. Liu’s research expertise is gene regulation, gene therapy and molecular mechanisms of cardiovascular diseases. He discovered the hypersensitive site 2 and the key regulatory sites in beta-globin gene cluster (PNAS, 1992). Dr. Liu found that myleran could increase gene expression of fetal globin in anemic rhesus monkeys and patients (American Journal of Hematology, 1990). He and his group discovered that thymidine treatment of cells could increase efficiency of oligonucleotide-mediated gene repair and thus raised the hypothesis of “replication fork leakage” (PNAS, 2005). His works systematically characterized the higher-order chromatin structure organization and its roles in gene transcriptional regulation, using the alpha-, beta-globin gene clusters and other clustered genes as the models.
He and his group found that the actively transcribed genes and multiple hypersensitive sites of alpha-globin gene cluster forms an active chromatin hub (ACH) in erythroid cells and that the alpha-globin ACH co-localizes with transcriptional factory formed by surrounding housekeeping genes (Mol Cell Biol, 2006).
Cardiovascular diseases are the leading cause of death. He and his group work on the molecular mechanisms of cardiovascular diseases. They found that human paraoxonase gene cluster transgenic overexpression not only represses atherogenesis but also promotes atherosclerotic plaque stability in vivo (Circ Res, 2011), thus they summarize that the paraoxonase gene cluster as a target in the treatment of atherosclerosis (Antioxid Redox Signal, 2012). They demonstrated for the first time the beneficial effects for histone deacetylase SIRT1 in preventing atherosclerotic diseases (Cardiovasc Res, 2008; Circ Res, 2011) and in inhibiting neointima formation (Circ Res, 2011), found that SIRT2 Acts as a cardioprotective deacetylase in pathological cardiac hypertrophy (Circulation, 2017), and demonstrated that SIRT4 plays crucial roles in mediating AngII-induced cardiac hypertrophy, thus acting as a potential therapeutic target (Eur Heart J, 2016). They found that calorie restriction increases SIRT1 expression and ameliorate abdominal aortic aneurysm (J Exp Med, 2016) while aging decreases SIRT1 expression and accelerates abdominal aortic aneurysm (Circ Res, 2016). They published a review about the four layers of aging (Cell System, 2015). Dr. De-Pei Liu has published more than 200 original research articles and invited reviews, which have been cited more than 5000 times.