Dr. Filippo Pinto e Vairo is a medical geneticist and genomics researcher at Mayo Clinic, where he serves as Medical Director of the Program for Rare and Undiagnosed Diseases (PRaUD) bridging clinical and translational research across various departments and divisions, focusing on genetics and rare diseases. Also, he is Associate Professor of Medical Genetics at the Mayo Clinic College of Medicine and Science. He is the Associate Director of the Translational Omics Program (TOP) where he has been aiding in establishing several innovative techniques to assist patient practice in individualized medicine. He is part of expert panels in lysosomal and kidney diseases within ClinGen, a NIH-funded resource aimed at defining the clinical relevance of genes and variants and he is also part of the National Organization for Rare Diseases (NORD) Data Sharing Working Group which aims at establishing the best practices and facilitate data sharing in the rare disease space to increase the number of diagnosed patients. Through his roles across clinical genomics and individualized medicine, he leads multidisciplinary efforts to advance genomic medicine, implement innovative diagnostic methodologies, and expand access to precision‑based approaches for patients with complex and unsolved conditions.