Advancing inclusive science diplomacy is critical to ensuring that Africa’s scientific perspectives are both heard and influential in global decision-making processes. The report African Women Scientists Driving Science Diplomacy in Times of Crisis offers an in-depth examination of the ways African women scientists are contributing to science, policy, and diplomacy within the continent and internationally, particularly in the face of challenges such as climate change, health emergencies, and socio-political instability. Through case studies, institutional profiles, and policy analysis, the report highlights practical pathways to strengthen gender equity in science leadership and international cooperation. It emphasizes that amid intersecting climate, health, and socioeconomic crises, the leadership of African women scientists is indispensable to enhancing Africa’s science diplomacy capacity and advancing coordinated, evidence-based responses.