The Fifteenth Annual Meeting of African Science Academies (AMASA-15) was held in Accra, Ghana on 13–16 November 2019. The primary focus of the AMASA-15 was to discuss how science, technology and innovation can be utilised to address issues of food security and poverty alleviation in Africa. The theme of the meeting was, ‘Science, Technology and Innovation for Food Security and Poverty Alleviation in Africa: The Role of Academies’.