Shekhar C. Mande (born 5 April 1962 in Pune, India) is an Indian structural and computational biologist known for his contributions to protein structure and computational biology. He completed his B.Sc. and M.Sc. in Physics at Nagpur University and earned a Ph.D. in Molecular Biophysics from the Indian Institute of Science, Bangalore. He pursued postdoctoral research at Rijksuniversiteit Groningen in the Netherlands and at the University of Washington, Seattle. 

Mande has held various scientific leadership positions, including Director of the National Centre for Cell Science (2011–2018), Director General of the Council of Scientific and Industrial Research (CSIR), and Secretary of the Department of Scientific and Industrial Research (DSIR), Government of India. He is a Distinguished Professor at the Bioinformatics Centre, Savitribai Phule Pune University. 

His research spans structural characterization of proteins and computational analysis of biological systems. He received the Shanti Swarup Bhatnagar Prize for Science and Technology in Biological Sciences in 2005, one of India’s top science awards. He is an elected fellow of major Indian science academies. 

In 2026, Mande assumed the role of President of the Indian National Science Academy (INSA), reflecting his longstanding leadership in Indian scientific institutions.